High-resolution quantitative trait locus mapping for body weight in mice by recombinant progeny testing
نویسندگان
چکیده
منابع مشابه
Mapping an overdominant quantitative trait locus for heterosis of body weight in mice.
The genetic basis of heterosis has not been elucidated. Previously, a congenic mouse strain with a 44-Mb genomic region of proximal chromosome 2 containing the allele derived from wild Mus musculus castaneus at Pbwg1, a quantitative trait locus (QTL) for body weight and growth, has been developed. In this study, to fine-map and characterize body weight QTLs on the congenic region, QTL analysis ...
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Genetic mapping studies in the mouse and other model organisms are used to search for genes underlying complex phenotypes. Traditional genetic mapping studies that employ single-generation crosses have poor mapping resolution and limit discovery to loci that are polymorphic between the two parental strains. Multiparent outbreeding populations address these shortcomings by increasing the density...
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In the quest for fine mapping quantitative trait loci (QTL) at a subcentimorgan scale, several methods that involve the construction of inbred lines and the generation of large progenies of such inbred lines have been developed (Complex Trait Consortium 2003). Here we present an alternative method that significantly speeds up QTL fine mapping by using one segregating population. As a first step...
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Selective recombinant genotyping (SRG) is a three-stage procedure for high-resolution mapping of a QTL that has previously been mapped to a known confidence interval (target C.I.). In stage 1, a large mapping population is accessed and phenotyped, and a proportion, P, of the high and low tails is selected. In stage 2, the selected individuals are genotyped for a pair of markers flanking the tar...
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Body weight (BW) and carcass traits are complex and important economic traits that may benefit from the implementation of MAS. The objective of the current study was to identify QTL associated with BW and carcass traits in an experimental half-sib cross of Japanese quails selected for BW at 4 weeks of age. Body weight and carcass traits were measured in the F2 population. Total F2 individuals a...
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ژورنال
عنوان ژورنال: Genetical Research
سال: 2001
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672301004943